That brings us to this trailer for a comedy starring the pair, The Sisters Brothers. It's a western-comedy to be precise, and Jake Gyllenhaal plays the villain. We think.
Here's what we learn in the trailer: Gold is involved, with Gyllenhaal and co-star Riz Ahmed on the hunt for it. Phoenix and Reilly are assassins, and they're apparently pretty good at their jobs. Here's the brief synopsis: "Based on Patrick Dewitt's acclaimed novel of the same name, follows two brothers - Eli and Charlie Sisters - who are hired to kill a prospector who has stolen from their boss. The story, a genre-hybrid with comedic elements, takes place in Oregon in 1851..."
Clear enough, right?
Anyway, Reilly not only stars in this movie, his production company originally purchased the rights to the story.
Comedy-westerns (or the other way around) are tricky to pull off. For every Blazing Saddles, there's a City Slickers II: The Legend of Curly's Gold.
But we have some confidence in John C. Reilly.
Hopefully audiences will give The Sisters Brothers a shot when it premieres later in 2018.