With iconic, gripping performances in films like V for Vendetta and Black Swan, plus charmingly offbeat portrayals in flicks like Mars Attacks!, the newly 38-year-old exhibits a unique command over audiences across all walks of life.
Most recently, she made her directorial debut with the warmly-received war drama A Tale of Love and Darkness, in which Portman also starred and acted mostly in Hebrew.
Her portrayal of former First Lady Jackie Kennedy in Jackie was considered a career-best performance by many, and once again proved Natalie Portman is the real deal.
That said, we'll never forget this sizzling moment with Mila Kunis from Black Swan.
Or her brutal rap digs, which she once again delivered on Saturday Night Live.
To celebrate her 38th birthday, take a look at some of her most memorable looks in the slideshow above.